Polyvinylpyrrolidone (PVP) K90
Pharmaceutical Binder
Pharmaceutical Products

Polyvinylpyrrolidone (PVP) K90

High-molecular-weight PVP K90 designed for pharmaceutical applications requiring superior binding and film-forming properties. Our premium PVP delivers excellent tablet binding, outstanding film formation, and reliable solubility enhancement for advanced pharmaceutical formulations and controlled release systems.

  • Excellent Binding Properties
  • Superior Film-forming Ability
  • Outstanding Solubility
  • Pharmaceutical Grade Quality
  • Controlled Release Properties
  • USP/EP/BP Compliant
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Technical Specifications

Chemical Formula: (C6H9NO)n
CAS Number: 9003-39-8
EINECS Number: 201-800-4
K-Value: 85-95 (K90)
Physical State: White to cream-colored powder
Molecular Weight: 1,000,000-1,500,000 Da
Viscosity (5% solution): 300-700 mPa·s
pH (5% solution): 3.0-7.0
Loss on Drying: ≤5.0%
Residue on Ignition: ≤0.1%
Heavy Metals: ≤10 ppm
Solubility: Freely soluble in water and ethanol
Storage Conditions: Store below 25°C, dry place
Shelf Life: 5 years from manufacture date
Packaging Options: 1kg, 5kg, 25kg bags

Applications

Tablet Binding Agent
Film Coating
Controlled Release Matrix
Solubility Enhancement
Tablet Disintegrant
Stabilizer
Capsule Formulations
Injectable Solutions
Ophthalmic Preparations
Suspension Stabilizer
Sustained Release
Pharmaceutical Research

Industry-Specific Grades

DRAVYOM offers specialized PVP K90 grades tailored for specific pharmaceutical applications, ensuring optimal binding efficacy and regulatory compliance across diverse formulation requirements.

USP Grade (United States Pharmacopoeia)
K-Value: 85-95 Water Content: ≤5.0% Heavy Metals: ≤10 ppm Application: FDA approved formulations
EP Grade (European Pharmacopoeia)
pH Range: 3.0-7.0 Viscosity: 300-700 mPa·s Residue on Ignition: ≤0.1% Application: European market compliance
High Molecular Weight Grade
MW: >1,000,000 Da Enhanced Binding: Superior Film Formation: Excellent Application: Extended release formulations
Low Endotoxin Grade
Endotoxins: <0.25 EU/mg Sterility: Assured Particle Size: Controlled Application: Injectable preparations

Quality Standards

DRAVYOM's PVP K90 is manufactured under stringent cGMP protocols, meeting international pharmaceutical excipient standards including USP, EP, and FDA guidelines for binding applications.

cGMP Manufacturing Standards
USP/EP Grade Specifications
K-Value 85-95 Verified
Advanced Analytical Testing
Binding Efficacy Verified
Batch-to-Batch Consistency
Comprehensive COA Documentation
Controlled Storage & Shipping

Advanced Chemical Properties & Performance

Polyvinylpyrrolidone K90 exhibits exceptional polymer binding properties essential for pharmaceutical applications. Its ultra-pure composition and precise K-value ensure reliable performance in demanding tablet and film-forming formulations.

Molecular Properties
Molecular Weight: Variable (K-value dependent)
LogP: Hydrophilic
pKa: Not applicable
Bioavailability: Non-absorbed excipient
Physical Properties
Glass Transition: 150-180°C
Solubility (Water): Freely soluble
Crystalline Form: Amorphous polymer
Hygroscopicity: Hygroscopic
Pharmaceutical Performance
K-Value Range: 85-95
Binding Strength: High (K90 grade)
Selectivity: High-molecular weight binder
Stability: Stable in solid state
Purity Specifications
Assay: ≥98.0%
Water Content: ≤5.0%
Heavy Metals: ≤10 ppm
Residual Solvents: ICH Q3C compliant
Stability Properties
Shelf Life: 5 years (unopened)
Light Sensitivity: Not light sensitive
Temperature Stability: Stable at room temperature
pH Stability: Stable pH 1-14

Performance Characteristics

Detailed performance metrics demonstrate PVP K90 superiority in pharmaceutical applications with exceptional binding properties, film-forming capabilities, and reproducibility across diverse tablet and coating formulations.

Binding Properties

K-value: 85-95 (high molecular weight)

Superior tablet binding strength
Solubility

Complete water solubility

Enhanced dissolution properties
Stability

Solid state: >5 years stability

Long-term pharmaceutical integrity
Thermal Stability

Working range: 15-80°C processing

Stable during formulation
Batch Reproducibility

Variation: ±0.5% between batches

Consistent lot-to-lot performance
Shelf Stability

5 years under proper storage conditions

Extended pharmaceutical grade integrity

Safety Information

Pharmaceutical grade polymer excipient requiring standard handling. Handle with appropriate protective equipment in controlled environments. Avoid skin contact and inhalation. Follow cGMP guidelines for pharmaceutical excipients and ensure proper waste disposal procedures.

Pharmaceutical Excipient
Avoid Skin Contact
Avoid Inhalation

Storage & Handling

Store in original sealed containers in a cool, dry, well-ventilated area away from moisture. Keep containers tightly closed and protect from humidity. Use appropriate containment measures for pharmaceutical excipient handling.

Room temperature storage (15-25°C)
Protect from moisture
Original sealed containers
Pharmaceutical containment required

Chemical Mechanisms & Reaction Pathways

Polyvinylpyrrolidone K90 functions as a high-molecular-weight pharmaceutical binder and disintegrant with excellent solubility and biocompatibility, providing enhanced tablet integrity and dissolution characteristics through hydrogen bonding and hydrophilic matrix formation.

Binding Properties

Strong hydrogen bonding with pharmaceutical actives

Enhanced tablet cohesion and strength
Solubility Enhancement

Excellent water solubility and dissolution properties

Improved drug release characteristics
Biocompatibility

Non-toxic, physiologically inert pharmaceutical polymer

Safe for oral and topical applications
Film-Forming Ability

Forms flexible, transparent films upon drying

Protective coating applications

Regulatory Compliance & Documentation

Comprehensive regulatory compliance ensures global pharmaceutical acceptance with complete documentation packages supporting international drug development and manufacturing requirements.

USP Specifications

United States Pharmacopeia pharmaceutical grade compliance

EP Standards

European Pharmacopoeia specifications and testing protocols

ICH Guidelines

International harmonized pharmaceutical development standards

Global Regulatory

Multi-regional pharmaceutical registration support

DMF Support

Drug Master File preparation and regulatory submission

GMP Compliance

Good Manufacturing Practice certified production

Technical Support & Value-Added Services

DRAVYOM's pharmaceutical development team provides comprehensive formulation support, analytical method development, and regulatory assistance to optimize Polyvinylpyrrolidone K90 performance in pharmaceutical applications.

Formulation Development
  • Tablet formulation optimization
  • Sustained release matrix design
  • Dissolution enhancement strategies
  • Coating formulation development
Analytical Services
  • Method validation and transfer
  • Molecular weight determination
  • Viscosity testing programs
  • K-value characterization
Regulatory Support
  • Regulatory strategy development
  • Documentation preparation
  • Regulatory submission support
  • Global compliance guidance
Supply Solutions
  • Reliable supply chain management
  • Moisture-controlled packaging
  • Emergency supply arrangements
  • Global distribution network

Environmental Impact & Sustainability

Our Polyvinylpyrrolidone K90 production emphasizes environmental responsibility through sustainable pharmaceutical manufacturing practices, waste minimization, and comprehensive environmental impact management.

Green Chemistry

Environmentally conscious synthesis with minimal waste

Water Management

Advanced wastewater treatment and recycling systems

Energy Efficiency

Optimized manufacturing processes with reduced energy consumption

Waste Reduction

Comprehensive waste minimization and disposal protocols

ISO 14001

Environmental management system certified production

Carbon Footprint

Reduced environmental impact through sustainable practices

Manufacturing Excellence & Quality Control

DRAVYOM's state-of-the-art pharmaceutical manufacturing facility employs advanced synthesis technology and continuous monitoring systems to ensure consistent Polyvinylpyrrolidone K90 quality and performance across all production batches.

GMP Production

Good Manufacturing Practice certified facility with controlled environments

Pharmaceutical-grade production standards
Quality Testing

Comprehensive analytical testing including K-value and molecular weight

GPC, viscometry, and solution testing
Quality Systems

ISO 9001:2015 quality management with pharmaceutical compliance

Continuous improvement and validation protocols
Packaging Control

Moisture-controlled packaging with desiccant protection

Stability maintenance and quality assurance

Market Applications & Performance Data

Comprehensive pharmaceutical data demonstrating Polyvinylpyrrolidone K90 effectiveness across diverse therapeutic applications with quantified performance metrics and regulatory validation.

Pharmaceutical Manufacturing
K-Value: 88-96 (high molecular weight) Molecular Weight: ~1,300,000 Da Purity: >99% pharmaceutical grade
Drug Development
Formulation Support: Tablets and coatings Regulatory Success: Global approvals achieved Innovation: Sustained release technologies
Clinical Applications
Safety: GRAS status pharmaceutical excipient Efficacy: Enhanced tablet properties Versatility: Multiple pharmaceutical applications

DRAVYOM Competitive Advantages

Pharmaceutical Excellence

Consistently exceeds USP/EP specifications with pharmaceutical-grade quality and performance

Reliable Supply

Guaranteed availability with strategic inventory management and pharmaceutical-grade production

Development Expertise

Dedicated pharmaceutical team provides formulation development and regulatory support

Quality Assurance

Comprehensive documentation with pharmaceutical-grade certificates and regulatory compliance

Global Standards

International compliance with USP, EP, and ICH guidelines for worldwide acceptance

Partnership Approach

Collaborative relationships with pharmaceutical companies and custom development services