Vitamin B12 (Cobalamin)
Biotechnology Premium
Essential B Vitamin

Vitamin B12 (Cobalamin)

High-quality Vitamin B12 (Cobalamin) for neurological research, cell culture studies, and metabolic applications. Premium grade essential vitamin manufactured for biotechnology research and cellular metabolism studies.

  • Essential B-Complex Vitamin
  • Neurological Research Applications
  • DNA Synthesis Cofactor
  • Cell Culture Compatible
  • High Purity Cobalamin
  • Research Standard Quality
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Technical Specifications

Chemical Name: Cyanocobalamin
CAS Number: 68-19-9
Molecular Formula: C63H88CoN14O14P
Molecular Weight: 1355.37 g/mol
Physical State: Dark red crystalline powder
Purity: ≥98.0% (HPLC)
Solubility: Water (12.5 g/L at 25°C)
Absorption Maximum: 361 nm, 278 nm
pH (1% solution): 4.5-7.0
Specific Activity: ≥97.0 μg/mg
Heavy Metals: ≤20 ppm
Loss on Drying: ≤12.0%
Residue on Ignition: ≤0.3%
Storage Temperature: 2-8°C, protect from light
Packaging: 10mg, 25mg, 100mg amber vials

Applications

Neurological Research
DNA Synthesis Studies
Hematology Research
Metabolic Studies
Enzyme Cofactor Research
Cell Culture Supplementation
Pharmaceutical Research
Nutritional Biochemistry
Methylation Studies

Industry-Specific Grades

DRAVYOM offers specialized Vitamin B12 grades tailored for specific biotechnology and research requirements, ensuring optimal performance and regulatory compliance across diverse applications.

Research Grade
Purity: ≥98.0% Heavy Metals: ≤20 ppm Loss on Drying: ≤12.0% Application: General research, biochemistry
Cell Culture Grade
Purity: ≥99.0% Endotoxin: <0.1 EU/mg Sterile Filtered: 0.2 μm Application: Cell culture, tissue engineering
Pharmaceutical Grade
Purity: ≥99.5% (USP) Specific Activity: ≥97.0 μg/mg Microbial Limits: USP compliant Application: Drug formulation, clinical research
Neurological Grade
Purity: ≥99.2% Cobalt Content: Verified Absorption: 361 nm verified Application: Neurological studies, dementia research

Quality Standards

DRAVYOM's Vitamin B12 is manufactured under stringent quality control protocols, meeting international standards including USP, BP, and research-grade specifications for biotechnology applications.

ISO 9001:2015 Certified Manufacturing
USP/BP Grade Specifications
≥98.0% HPLC Purity
Advanced Spectroscopic Testing
Cobalt Content Verified
Light-Protected Storage
Certificate of Analysis Provided
Cold Chain Logistics

Advanced Chemical Properties & Performance

Vitamin B12 exhibits exceptional cobalt-containing corrinoid properties essential for biological applications. Its complex molecular structure and high purity ensure reliable performance in demanding neurological research and metabolic studies.

Biochemical Properties
Cobalt Coordination: Co³⁺ central metal ion
Corrin Ring: Tetrapyrrole macrocycle
Cofactor Activity: Methylmalonyl-CoA mutase
Binding Affinity: Intrinsic factor Kd: 1 nM
Physical Properties
Crystal Structure: Dark red crystals
Specific Activity: ≥97 μg/mg dry weight
UV-Vis Spectrum: λmax 361, 278 nm
Molar Absorption: ε361 = 28,000 M⁻¹cm⁻¹
Metabolic Performance
DNA Synthesis: Methionine synthase cofactor
Methylation Cycle: Homocysteine metabolism
Cellular Uptake: Receptor-mediated endocytosis
Stability in Serum: 72h at 37°C (90% retention)
Purity Specifications
Total Impurities: ≤ 2.0%
Related Cobalamins: ≤ 1.0% each
Water Content: ≤ 12.0%
Color Intensity: Dark red crystalline
Stability Properties
Shelf Life: 5 years (unopened, dark)
Light Sensitivity: Photolabile, protect from light
pH Stability: Stable pH 4-7
Thermal Stability: Stable below 40°C

Performance Characteristics

Detailed performance metrics demonstrate Vitamin B12 superiority in neurological applications with exceptional bioactivity, cofactor function, and reproducibility across diverse research protocols and cellular studies.

Neurological Activity

Myelin synthesis: 95% cofactor efficiency

Essential for nerve function
DNA Synthesis Support

Methionine synthase: 98% activation

Critical for cell division
Metabolic Cofactor

Methylmalonyl-CoA mutase: 100% activity

Essential fatty acid metabolism
Temperature Stability

Working range: 2-8°C storage

Maintains activity under refrigeration
Batch Reproducibility

Variation: ±3% between batches

Consistent bioactivity performance
Stability Performance

5 years under proper storage conditions

Extended vitamin integrity

Safety Information

Generally recognized as safe (GRAS) essential vitamin for research applications. Handle with standard laboratory precautions including safety goggles and gloves. Non-toxic and well-tolerated. May cause mild skin irritation in sensitive individuals. Contains cobalt - monitor for metal sensitivities.

GRAS Essential Vitamin
Contains Cobalt
Standard Lab Precautions

Storage & Handling

Store in original amber containers in a cool, dry, dark place away from light. Keep containers tightly closed with desiccant. Highly photosensitive - protect from all light sources. Use under red light or darkness when handling. Stable for extended periods when properly stored.

Cold storage (2-8°C)
Strict light protection required
Amber containers with desiccant
Dry, low-humidity environment

Chemical Mechanisms & Reaction Pathways

Vitamin B12 exhibits essential coenzyme properties through its cobalt-corrin complex structure, enabling precise metabolic pathway participation with predictable enzymatic interactions and quantitative cellular functions.

Methyl Transfer

Coenzyme in methionine synthase for methylation reactions

Essential for DNA methylation studies
Fatty Acid Metabolism

Cofactor for methylmalonyl-CoA mutase enzyme

Critical for metabolic pathway research
Neurological Function

Essential for myelin synthesis and nerve function

Important for neuroscience applications
Hematopoiesis

Required for red blood cell maturation and formation

Key for hematology studies

Regulatory Compliance & Documentation

Comprehensive regulatory compliance ensures global biotechnology laboratory access with complete documentation packages supporting international standards and biochemical method validations.

Research Grade

Ultra-pure specifications for biochemical research applications

ISO 6353 Standard

International standard for reagent specifications and testing

USP Grade Available

United States Pharmacopeia specifications for pharmaceutical research

REACH Registration

European Union chemical regulation compliance

Method Validation

Supported biochemical method validation documentation

SDS Documentation

Multi-language Safety Data Sheets (16 sections, GHS compliant)

Technical Support & Value-Added Services

DRAVYOM's biochemistry team provides comprehensive method support, troubleshooting assistance, and biotechnology services to optimize Vitamin B12 performance in your specific research applications.

Method Development
  • Assay optimization support
  • Stability and storage guidance
  • Activity measurement validation
  • Custom vitamin formulations
Analytical Services
  • Certificate of Analysis verification
  • Potency and purity analysis
  • Photostability testing
  • Microbiological validation
Technical Support
  • Research troubleshooting consultation
  • Light protection guidance
  • Handling and storage protocols
  • Laboratory best practices
Supply Solutions
  • Consistent lot scheduling
  • Emergency supply arrangements
  • Light-protected packaging
  • Cold chain distribution

Environmental Impact & Sustainability

Our Vitamin B12 production emphasizes environmental responsibility through sustainable manufacturing practices, waste minimization, and comprehensive environmental impact management for biochemical laboratory operations.

Waste Minimization

Optimized production with minimal waste generation

Water Treatment

Advanced wastewater treatment and recycling systems

Clean Production

Energy-efficient synthesis with emission controls

Safe Disposal

Comprehensive guidance for laboratory waste management

ISO 14001

Environmental management system certified production

Container Recycling

Container return and recycling programs

Manufacturing Excellence & Quality Control

DRAVYOM's state-of-the-art biotechnology facility employs advanced purification technology and continuous monitoring systems to ensure consistent Vitamin B12 quality and performance across all production batches.

Production Process

Advanced crystallization and purification in controlled light-protected environment

Multi-stage purification for research grade quality
Quality Testing

Comprehensive testing including potency, photostability, and cobalt content

HPLC verification and microbiological analysis
Quality Systems

ISO 9001:2015 quality management with biochemistry laboratory accreditation

Continuous improvement and bioprocess validation
Packaging Control

Amber containers with desiccant and controlled atmosphere packaging

Complete light protection and moisture control

Market Applications & Performance Data

Comprehensive biochemistry laboratory data demonstrating Vitamin B12 effectiveness across diverse applications with quantified performance metrics and research method validations.

Biochemistry Labs
Activity Retention: >95% potency after 2 years storage Purity: >99% by HPLC analysis Enzyme Function: 100% cofactor activity retention
Research Institutions
Publication Support: 400+ cited protocols Reproducibility: >99% inter-lab agreement Innovation: Custom vitamin formulations
Biotech Companies
Reliability: 99.9% lot consistency Audit Success: 100% regulatory compliance Efficiency: 20% improved assay performance

DRAVYOM Competitive Advantages

Superior Purity

Consistently exceeds research specifications with ultra-high potency and exceptional photostability

Reliable Supply

Guaranteed availability with strategic inventory management and research-grade production scheduling

Biochemistry Expertise

Dedicated vitamin research team provides assay development and troubleshooting support

Quality Assurance

Traceable certificates with comprehensive potency analysis and stability validation support

Global Standards

International compliance with research and USP specifications for worldwide acceptance

Partnership Approach

Collaborative relationships with biochemistry laboratories and custom vitamin development services