HATU Peptide Coupling Reagent
Biotechnology Premium
Peptide Coupling Reagent

HATU Peptide Coupling Reagent

High-quality HATU for peptide synthesis, amide bond formation, and protein chemistry. Premium grade coupling reagent manufactured for efficient peptide manufacturing and research applications.

  • Efficient Amide Bond Formation
  • Peptide Synthesis Compatible
  • High Coupling Efficiency
  • Protein Chemistry Applications
  • Synthesis Grade Purity
  • Research Standard Quality
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Technical Specifications

Chemical Name: 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate
CAS Number: 148893-10-1
Molecular Formula: C10H16F6N5OP
Molecular Weight: 379.23 g/mol
Physical State: White to off-white crystalline powder
Melting Point: 164-166°C
Solubility: DMF, DMSO, DCM, acetonitrile
Storage Temperature: -20°C (Long-term), 2-8°C (Working)
Purity: ≥98% (HPLC)
Water Content: ≤1.0% (Karl Fischer)
Coupling Efficiency: ≥95% (Standard conditions)
Packaging Options: 1g, 5g, 25g containers

Applications

Peptide Synthesis
Amide Bond Formation
Protein Chemistry
Solid-Phase Synthesis
Solution-Phase Coupling
Research Applications
Bioconjugation
Pharmaceutical Synthesis
Natural Product Synthesis
Drug Discovery
Chemical Biology
Quality Control

Industry-Specific Grades

DRAVYOM offers specialized HATU grades tailored for specific peptide synthesis and coupling applications, ensuring optimal performance and regulatory compliance across diverse research and pharmaceutical applications.

Research Grade
Purity: ≥98% (HPLC) Water Content: ≤1.0% Coupling Efficiency: ≥95% Application: Basic peptide synthesis
Pharmaceutical Grade
Purity: ≥99% (HPLC) Heavy Metals: <10 ppm Residual Solvents: USP limits Application: Drug development
High-Performance Grade
Purity: ≥99.5% (HPLC) Coupling Efficiency: ≥98% Epimerization: <0.1% Application: Complex peptides
Ultra-Pure Grade
Purity: ≥99.9% (HPLC) Endotoxin: <0.25 EU/mg Sterility: Tested Application: Critical synthesis

Quality Standards

DRAVYOM's HATU is manufactured under stringent quality control protocols, meeting international pharmaceutical standards including GMP, ICH, and research specifications. Our synthesis-grade production ensures consistent coupling performance and regulatory compliance.

ISO 9001:2015 Certified Manufacturing
GMP Compliant Production
≥98% HPLC Verified Purity
Coupling Efficiency Testing
Epimerization Control
Batch-to-Batch Consistency
Certificate of Analysis
Cold Chain Logistics

Advanced Chemical Properties & Performance

HATU exhibits exceptional peptide coupling properties essential for solid-phase peptide synthesis applications. Its high reactivity and minimal racemization ensure reliable performance in demanding peptide synthesis protocols, amide bond formation studies, and pharmaceutical synthesis procedures.

Coupling Agent Properties
Molecular Weight: 380.23 g/mol
Chemical Formula: C₁₁H₁₆N₅O₄PF₆
Coupling Agent Type: Uronium-based activator
Reactivity: Highly reactive coupling agent
Physical Properties
Appearance: White to off-white powder
Melting Point: 195-200°C (decomposition)
Solubility: DMF, DMSO, acetonitrile
Stability: Moisture sensitive
Coupling Performance
Coupling Efficiency: 95-99% coupling yield
Racemization: Minimal (<0.5%)
Reaction Time: 15-60 minutes
Equivalent Ratio: 1.1-1.5 equiv
Purity Specifications
Assay (by HPLC): ≥ 98.0%
Water Content: ≤ 0.3%
Heavy Metals: ≤ 10 ppm
Related Substances: ≤ 1.0% each
Stability Properties
Shelf Life: 2 years (-20°C, dry)
Solution Stability: Use immediately
Moisture Sensitivity: Highly moisture sensitive
Light Sensitivity: Protect from light

Performance Characteristics

Detailed performance metrics demonstrate HATU superiority in peptide synthesis applications with exceptional coupling efficiency, minimal racemization, and reproducibility across diverse peptide synthesis protocols and pharmaceutical manufacturing procedures.

Coupling Efficiency

Yield: 95-99%

Exceptional amide bond formation
Racemization

Stereochemical integrity: <0.5%

Minimal chiral center loss
Reaction Time

Coupling time: 15-60 minutes

Rapid coupling kinetics
Temperature Range

Working range: 0-25°C

Mild reaction conditions
Batch Reproducibility

Variation: ±1% between batches

Consistent coupling performance
Storage Stability

2 years under proper storage

Extended reagent integrity

Safety Information

Handle with caution - reactive coupling agent. Use specialized safety equipment including safety goggles, gloves, and lab coat. May cause skin and eye irritation. Avoid inhalation of powder. Use only in well-ventilated areas or fume hood. Keep away from water and moisture. Follow proper disposal procedures.

Irritant
Moisture Sensitive
Use in Fume Hood

Storage & Handling

Store in original containers at -20°C in a dry environment under inert atmosphere. Keep containers tightly closed and use desiccants. Protect from light and moisture. Handle in dry glove box or under nitrogen atmosphere. Use immediately after opening. Dispose of according to local regulations.

Frozen storage (-20°C)
Inert atmosphere required
Protect from light
Handle in dry glove box

Chemical Mechanisms & Reaction Pathways

HATU provides efficient peptide coupling through activated phosphonium chemistry, enabling precise bioconjugation applications with predictable amide bond formation and quantitative coupling efficiency for synthetic protocols.

Peptide Coupling

Activated ester formation for efficient amide bond synthesis

Essential for peptide synthesis
Phosphonium Activation

Phosphonium intermediate formation for reactive coupling

Critical for high efficiency
Bioconjugation

Protein modification and labeling chemistry

Enables protein engineering
Solid Phase Synthesis

Resin-bound peptide coupling optimization

Supporting automated synthesis

Regulatory Compliance & Documentation

Comprehensive regulatory compliance ensures global peptide synthesis laboratory access with complete documentation packages supporting international standards and coupling reagent method validations.

Research Grade Standards

High purity specifications for peptide synthesis applications

ISO Standards

International standard compliance for research reagent specifications

Synthesis Grade

Synthesis grade specifications for peptide coupling studies

Global Compliance

International synthetic chemistry research regulation compliance

Method Validation

Supported coupling reagent method validation documentation

SDS Documentation

Multi-language Safety Data Sheets (16 sections, GHS compliant)

Technical Support & Value-Added Services

DRAVYOM's synthetic chemistry team provides comprehensive method support, troubleshooting assistance, and coupling services to optimize HATU performance in your specific research applications.

Method Development
  • Peptide coupling optimization support
  • Synthesis protocol guidance
  • Coupling chemistry methods
  • Custom synthesis procedures
Research Services
  • Certificate of Analysis verification
  • Custom purity analysis
  • Coupling efficiency testing
  • Synthetic chemistry method validation support
Technical Support
  • Synthesis troubleshooting consultation
  • Storage and handling guidance
  • Laboratory safety protocols
  • Research best practices
Supply Solutions
  • Consistent batch scheduling
  • Emergency supply arrangements
  • Custom packaging options
  • Global distribution network

Environmental Impact & Sustainability

Our HATU production emphasizes environmental responsibility through sustainable synthetic chemistry practices, waste minimization, and comprehensive environmental impact management for peptide synthesis research operations.

Waste Minimization

Optimized coupling reagent synthesis with minimal waste generation

Water Treatment

Advanced wastewater treatment and recycling systems

Green Production

Energy-efficient synthesis processing with emission controls

Safe Disposal

Comprehensive guidance for coupling reagent waste management

ISO 14001

Environmental management system certified production

Container Recycling

Sustainable container return and recycling programs

Manufacturing Excellence & Quality Control

DRAVYOM's state-of-the-art synthetic chemistry facility employs advanced purification technology and continuous monitoring systems to ensure consistent research-grade HATU quality and performance across all production batches.

Production Process

Advanced coupling reagent synthesis and purification in controlled environment

Multi-stage purification for research grade quality
Quality Testing

Comprehensive analytical testing including NMR and mass spectrometry

HATU content verification and purity analysis
Quality Systems

ISO 9001:2015 quality management with synthetic chemistry laboratory accreditation

Continuous improvement and method validation
Packaging Control

Moisture-free containers with inert atmosphere packaging

Hydrolysis protection and contamination prevention

Market Applications & Performance Data

Comprehensive peptide synthesis research data demonstrating HATU effectiveness across diverse applications with quantified performance metrics and coupling reagent method validations.

Research Laboratories
Purity: >98% coupling reagent content Performance: Efficient peptide coupling Stability: 12+ months under inert conditions
Academic Institutions
Publication Support: 15000+ cited syntheses Reproducibility: >99% inter-lab agreement Innovation: Custom coupling solutions
Pharmaceutical Companies
Reliability: 99.5% batch consistency Quality Assurance: Validated coupling performance Efficiency: Optimized synthesis protocols

DRAVYOM Competitive Advantages

Superior Purity

Consistently exceeds research specifications with ultra-high purity and exceptional coupling performance

Reliable Supply

Guaranteed availability with strategic inventory management and research-grade production scheduling

Synthetic Chemistry Expertise

Dedicated synthetic chemistry team provides coupling optimization and troubleshooting support

Quality Assurance

Comprehensive certificates with detailed coupling performance data and method validation support

Global Standards

International compliance with research specifications for worldwide acceptance

Partnership Approach

Collaborative relationships with research laboratories and custom grade development services