DAPI Fluorescent Nuclear Stain
Biotechnology Premium
Nuclear Fluorescent Stain

DAPI Fluorescent Nuclear Stain

High-quality DAPI (4',6-diamidino-2-phenylindole) for fluorescence microscopy and nuclear staining. Premium grade fluorescent dye manufactured for DNA visualization and cell counting applications.

  • Nuclear DNA Binding
  • UV Fluorescence Excitation
  • High Specificity for DNA
  • Cell Counting Compatible
  • Microscopy Grade Purity
  • Research Grade Quality

Technical Specifications

Chemical Name: 4',6-diamidino-2-phenylindole
CAS Number: 28718-90-3
Molecular Formula: C16H15N5
Molecular Weight: 277.32 g/mol
Physical State: Yellow crystalline powder
Excitation Maximum: 358 nm (UV)
Emission Maximum: 461 nm (Blue)
Solubility: Water, DMSO, DMF
Storage Temperature: -20°C (Protected from light)
Purity: ≥98% (HPLC)
Working Concentration: 0.1-1.0 μg/ml
Packaging Options: 1mg, 5mg, 10mg vials

Applications

Nuclear DNA Staining
Fluorescence Microscopy
Cell Counting
Flow Cytometry
Chromosome Visualization
Cell Biology Research
Apoptosis Studies
Immunofluorescence
Plant Cell Studies
Live Cell Imaging
Nuclear Morphology
Quality Control

Industry-Specific Grades

DRAVYOM offers specialized DAPI grades tailored for specific research and diagnostic applications, ensuring optimal fluorescence performance and regulatory compliance across diverse biotechnology applications.

Research Grade
Purity: ≥98% (HPLC) Fluorescence Intensity: High Background: Low Application: Basic research, cell studies
Microscopy Grade
Purity: ≥99% (HPLC) Photobleaching: Minimal Signal Stability: Excellent Application: High-resolution imaging
Flow Cytometry Grade
Purity: ≥99.5% (HPLC) Uniformity: Excellent Aggregation: None Application: Flow cytometry analysis
Clinical Grade
Purity: ≥99.9% (HPLC) Endotoxin: <1 EU/mg Sterility: Tested Application: Diagnostic applications

Quality Standards

DRAVYOM's DAPI is manufactured under stringent quality control protocols, meeting international biotechnology standards including ISO, cGMP, and research specifications. Our analytical-grade production ensures consistent fluorescence performance and regulatory compliance.

ISO 9001:2015 Certified Manufacturing
cGMP Compliant Production
≥98% HPLC Verified Purity
Advanced Fluorescence Testing
Photobleaching Resistance
Batch-to-Batch Consistency
Certificate of Analysis
Cold Chain Logistics

Advanced Chemical Properties & Performance

DAPI exhibits exceptional fluorescent dye properties essential for nucleic acid visualization applications. Its DNA-binding specificity and fluorescence enhancement ensure reliable performance in demanding microscopy protocols and cell nuclear staining studies.

Fluorescent Properties
Molecular Weight: 350.25 Da
Excitation Maximum: 358 nm
Emission Maximum: 461 nm
Quantum Yield: 0.27 (DNA-bound)
Physical Properties
Appearance: Yellow crystalline powder
Solubility: Water, DMSO soluble
Fluorescence Color: Blue (DNA-bound)
Stokes Shift: 103 nm
DNA Binding Performance
DNA Binding: Minor groove interaction
Binding Constant: Kd = 4.3 × 10⁻⁸ M
Selectivity: AT-rich sequences preferred
Fluorescence Enhancement: 20-fold upon DNA binding
Purity Specifications
Dye Purity: ≥ 95% (HPLC)
Fluorescence Quality: Nuclear staining specific
Heavy Metals: ≤ 50 ppm
Water Content: ≤ 2%
Stability Properties
Shelf Life: 3 years (-20°C, dark)
Photostability: Moderate photobleaching
Solution Stability: 1 week at 4°C (dark)
pH Stability: Stable pH 6-8

Performance Characteristics

Detailed performance metrics demonstrate DAPI superiority in fluorescence microscopy applications with exceptional DNA binding specificity, fluorescence enhancement, and reproducibility across diverse nuclear staining protocols and cell imaging studies.

Fluorescence Enhancement

Enhancement: 20-fold upon DNA binding

Strong fluorescence signal
DNA Binding Specificity

Minor groove binding: AT-rich regions

Selective nucleic acid interaction
Nuclear Staining

Staining concentration: 0.1-1 μg/mL

Excellent nuclear visualization
Temperature Stability

Working range: 4-37°C

Stable across biological temperatures
Batch Reproducibility

Fluorescence variation: ±5%

Consistent staining performance
Stability Performance

3 years under proper storage

Extended fluorophore integrity

Safety Information

Potential mutagen requiring special handling precautions. Handle with standard laboratory safety equipment including safety goggles, gloves, and lab coat. Avoid inhalation of powder and skin contact. DNA-binding agent - handle in well-ventilated areas. Dispose according to hazardous waste regulations.

Potential Mutagen
Avoid Skin Contact
Use with Ventilation

Storage & Handling

Store in original containers at -20°C in a dark, dry environment. Keep containers tightly closed with desiccant. Protect from light during storage and use. Prepare working solutions fresh and use immediately for optimal fluorescence.

Frozen storage (-20°C)
Dark storage required
Desiccant required
Protect from light

Chemical Mechanisms & Reaction Pathways

DAPI binds to DNA through AT-rich region intercalation, enabling precise nuclear imaging applications with predictable fluorescence enhancement and quantitative nucleic acid detection for cell biology studies.

DNA Intercalation

Selective binding to AT-rich regions of double-stranded DNA

Essential for nuclear staining
Fluorescence Enhancement

20-fold fluorescence increase upon DNA binding

Critical for live cell imaging
Spectral Properties

Blue fluorescence with excitation at 358nm, emission at 461nm

Enables fluorescence microscopy
Cell Permeability

Membrane-permeable staining for live and fixed cells

Supporting cell viability studies

Regulatory Compliance & Documentation

Comprehensive regulatory compliance ensures global cell biology laboratory access with complete documentation packages supporting international standards and fluorescence imaging method validations.

Research Grade Standards

High purity specifications for cell biology applications

ISO Standards

International standard compliance for research reagent specifications

Fluorescence Grade

Fluorescence grade specifications for imaging studies

Global Compliance

International cell biology research regulation compliance

Method Validation

Supported fluorescence method validation documentation

SDS Documentation

Multi-language Safety Data Sheets (16 sections, GHS compliant)

Technical Support & Value-Added Services

DRAVYOM's cell biology team provides comprehensive method support, troubleshooting assistance, and fluorescence services to optimize DAPI performance in your specific research applications.

Method Development
  • Fluorescence microscopy optimization support
  • Cell staining protocol guidance
  • Imaging parameter development
  • Custom fluorescence procedures
Research Services
  • Certificate of Analysis verification
  • Custom purity analysis
  • Fluorescence quality testing
  • Cell biology method validation support
Technical Support
  • Fluorescence troubleshooting consultation
  • Storage and handling guidance
  • Laboratory safety protocols
  • Research best practices
Supply Solutions
  • Consistent batch scheduling
  • Emergency supply arrangements
  • Custom packaging options
  • Global distribution network

Environmental Impact & Sustainability

Our DAPI production emphasizes environmental responsibility through sustainable fluorophore synthesis practices, waste minimization, and comprehensive environmental impact management for cell biology research operations.

Waste Minimization

Optimized fluorophore synthesis with minimal waste generation

Water Treatment

Advanced wastewater treatment and recycling systems

Green Production

Energy-efficient fluorophore synthesis with emission controls

Safe Disposal

Comprehensive guidance for fluorophore waste management

ISO 14001

Environmental management system certified production

Container Recycling

Sustainable container return and recycling programs

Manufacturing Excellence & Quality Control

DRAVYOM's state-of-the-art fluorophore manufacturing facility employs advanced synthesis technology and continuous monitoring systems to ensure consistent research-grade DAPI quality and performance across all production batches.

Production Process

Advanced fluorophore synthesis and purification in controlled environment

Multi-stage purification for research grade quality
Quality Testing

Comprehensive analytical testing including fluorescence and DNA binding analysis

Spectrofluorometric verification and binding assays
Quality Systems

ISO 9001:2015 quality management with cell biology laboratory accreditation

Continuous improvement and method validation
Packaging Control

Light-protected containers with moisture and air exclusion

Fluorophore stability protection and contamination prevention

Market Applications & Performance Data

Comprehensive cell biology research data demonstrating DAPI effectiveness across diverse applications with quantified performance metrics and fluorescence imaging method validations.

Research Laboratories
Purity: >98% fluorophore content Sensitivity: Single cell nuclear detection Stability: 24+ months at -20°C
Academic Institutions
Publication Support: 10,000+ cited studies Reproducibility: >99% inter-lab agreement Innovation: Custom fluorescence solutions
Biotechnology Companies
Reliability: 99.8% batch consistency Quality Assurance: Validated fluorescence performance Efficiency: Optimized imaging protocols

DRAVYOM Competitive Advantages

Superior Purity

Consistently exceeds research specifications with ultra-high purity and exceptional fluorescence performance

Reliable Supply

Guaranteed availability with strategic inventory management and research-grade production scheduling

Cell Biology Expertise

Dedicated cell biology team provides fluorescence optimization and troubleshooting support

Quality Assurance

Comprehensive certificates with detailed fluorescence performance data and method validation support

Global Standards

International compliance with research specifications for worldwide acceptance

Partnership Approach

Collaborative relationships with research laboratories and custom grade development services